Was evaluated by the researchers in a previous experiment; nevertheless, they discovered that it only offered a limited level of protection against malaria.
In the hopes of improving the situation, the researchers created GA2, a different parasite, to cease growth in preclinical humanised mice models about six days after invasion.
According to the Vaccine Alliance, which is supported by Bill Gates, “because the parasite dies before it infects the blood cells and evolves into its deadly phase, it instead acts as a way of priming the immune system, as a vaccination usually would.”
In a test group consisting of forty-three adults aged 19 to 35 who had never been known to have contracted malaria, the researchers gave them three vaccination sessions spaced 28 days apart.
The subjects were given 50 bites from GA2-infected mosquitoes, 50 bites from GA1-infected mosquitoes, or 50 bites from uninfected mosquitoes (placebo).
Five bites from infected mosquitoes caused the human test volunteers to get malaria three weeks after they were consumed by mosquitoes for the third time.
