As a consequence, the family moved to the Hialeah, Florida area. Being a quiet youngster, D’Onofrio often retreated to his room to spend time reflecting.
While residing in Florida, he developed an interest in magic and sleight of hand after learning these skills from Cuban entertainers who owned a small magic store.
In the early 1990s, actress Greta Scacchi and actor Vincent D’Onofrio were romantically involved. They appeared together on screen in a number of movies during this period, such as The Player and Fires Within.
Born in 1991 or 1992, Leila George, their daughter from their relationship, has pursued a career in acting. In 1997, Vincent D’Onofrio wed Carin van der Donk, a Dutch model.
In 1999, they welcomed their first son together. However, issues in their relationship compelled them to break up in the early 2000s. They reconciled and had a second son in 2008.